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Prolaktinowye adenomy

Jeto bylo retrospektiwnoe, opisatel'noe i analiticheskoe issledowanie 77 sluchaew prolaktinomy, sobrannyh i proslezhennyh w otdelenii ändokrinologii i diabetologii uniwersitetskoj bol'nicy Hedi Chaker w Sfaxe w period s 2000 po 2017 god. Byli opisany razlichnye klinicheskie, paraklinicheskie i terapewticheskie harakteristiki. Nashi pacienty byli razdeleny na 3 gruppy w zawisimosti ot razmera prolaktinomy. Prowodilsq poisk statisticheskih korrelqcij mezhdu razmerom opuholi i klinicheskimi i biologicheskimi parametrami. Adenoma prolaktina izuchalas' u beremennyh zhenschin, pozhilyh lüdej i w sluchaqh, kogda ee obnaruzhenie bylo sluchajnym. Srednij wozrast nashih pacientow sostawil 38,3±14,2 let. Srednij wozrast nashih pacientow sostawil 38,3±14,2 let. 51 (66,2%) zhenschina i 26 (33,7%) muzhchin. Srednqq zaderzhka diagnostiki sostawila 47,37 mesqcew. Sindrom opuholi gipofiza byl obstoqtel'stwom obnaruzheniq w 62,3% sluchaew. Jendokrinnyj sindrom giperprolaktinemii proqwlqlsq u zhenschin narusheniqmi menstrual'nogo cikla (78,4%) i galaktoreej (70,5%). U muzhchin w klinicheskoj kartine preobladali ärektil'naq disfunkciq (42,3%) i/ili snizhenie libido (34,6%). Sindrom perednej gipofizarnoj nedostatochnosti nablüdalsq w 75,3% sluchaew. Kolichestwo gipofizarnyh deficitow znachitel'no korrelirowalo s razmerom opuholi. Srawniwaq tri gruppy, my otmetili, chto wozrast, CDD, metabolicheskie parametry, gipopituitarizm i rasshirenie gipofiza pri wizualizacii znachitel'no otlichalis'.

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Prolactin adenomas

This was a retrospective, descriptive and analytical study of 77 cases of prolactinomas collected and followed up in the endocrinology and diabetology department of the Hedi Chaker University Hospital of Sfax between 2000 and 2017. Different clinical, paraclinical and therapeutic characteristics were described. Our patients were divided into 3 groups according to the size of their prolactinomas. Statistical correlations were sought between tumor size and clinical and biological parameters. Prolactin adenoma was studied in pregnant women, elderly subjects and when its discovery was incidental.The average age of our patients was 38.3±14.2 years. The average age of our patients was 38.3±14.2 years. 51 (66.2%) were women and 26 (33.7%) were men. The diagnostic latency was 47.37 months on average. The pituitary tumor syndrome was a circumstance of discovery observed in 62.3% of cases. The endocrine syndrome of hyperprolactinemia was manifested in women by menstrual cycle disorders (78.4%) and galactorrhea (70.5%). In men, the clinical picture was dominated by erectile dysfunction (42.3%) and/or decreased libido (34.6%). The anteropituitary insufficiency syndrome was observed in 75.3% of cases. The number of anteropituitary deficits was significantly correlated with the tumor size. Comparing the three groups, we noted that age, CDD, metabolic parameters, hypopituitarism and pituitary extensions on imaging were significantly different

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Prolactin adenomas

Este foi um estudo retrospectivo, descritivo e analítico de 77 casos de prolactinoma coletados e acompanhados no departamento de endocrinologia e diabetologia do Hospital Universitário Hedi Chaker em Sfax entre 2000 e 2017. Foram descritas diferentes características clínicas, paraclínicas e terapêuticas. Nossos pacientes foram divididos em 3 grupos de acordo com o tamanho de seus prolactinomas. Foram procuradas correlações estatísticas entre o tamanho do tumor e os parâmetros clínicos e biológicos. O adenoma de prolactina foi estudado em gestantes, idosos e quando sua descoberta foi incidental, a idade média de nossos pacientes foi de 38,3±14,2 anos. A idade média dos nossos pacientes foi de 38,3±14,2 anos. 51 (66,2%) eram mulheres e 26 (33,7%) eram homens. A latência média de diagnóstico foi de 47,37 meses. A síndrome do tumor hipofisário foi uma circunstância de descoberta em 62,3% dos casos. A síndrome endócrina da hiperprolactinemia manifestou-se nas mulheres por distúrbios do ciclo menstrual (78,4%) e galactorreia (70,5%). Nos homens, o quadro clínico foi dominado pela disfunção erétil (42,3%) e/ou diminuição da libido (34,6%). A síndrome da insuficiência anteropituitária foi observada em 75,3% dos casos. O número de défices hipofisários estava significativamente correlacionado com o tamanho do tumor. Comparando os três grupos, notamos que idade, CDD, parâmetros metabólicos, hipopituitarismo e extensões pituitárias na imagem foram significativamente diferentes

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Adenomas de prolactina

Se trata de un estudio retrospectivo, descriptivo y analítico de 77 casos de prolactinoma recogidos y seguidos en el servicio de endocrinología y diabetología del Hospital Universitario Hedi Chaker de Sfax entre 2000 y 2017. Se describieron diferentes características clínicas, paraclínicas y terapéuticas. Nuestros pacientes fueron divididos en 3 grupos según el tamaño de sus prolactinomas. Se buscaron correlaciones estadísticas entre el tamaño del tumor y los parámetros clínicos y biológicos. El adenoma de prolactina se estudió en mujeres embarazadas, sujetos de edad avanzada y cuando su descubrimiento fue incidental.La edad media de nuestros pacientes fue de 38,3±14,2 años. La edad media de nuestros pacientes fue de 38,3±14,2 años. 51 (66,2%) eran mujeres y 26 (33,7%) eran hombres. La media de latencia diagnóstica fue de 47,37 meses. El síndrome tumoral hipofisario fue una circunstancia de descubrimiento en el 62,3% de los casos. El síndrome endocrino de la hiperprolactinemia se manifestó en las mujeres por trastornos del ciclo menstrual (78,4%) y galactorrea (70,5%). En los hombres, el cuadro clínico estaba dominado por la disfunción eréctil (42,3%) y/o la disminución de la libido (34,6%). El síndrome de insuficiencia anteropituitaria se observó en el 75,3% de los casos. El número de déficits hipofisarios estaba significativamente correlacionado con el tamaño del tumor. Al comparar los tres grupos, observamos que la edad, la DDC, los parámetros metabólicos, el hipopituitarismo y las extensiones hipofisarias en las imágenes eran significativamente diferentes

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Diagnostic Pathology: Head and Neck

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of head and neck pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Head and Neck is a one-stop reference for accurate, complete pathology reports-ideal as a day-to-day reference or as a reliable teaching resource. * Provides a clear framework for a better understanding of the clinical and histopathologic appearances of more than 325 new or evolving entities of the head and neck and endocrine organs * Features updates on recent changes in the field and current information from the AJCC Cancer Staging Manual, 8th Edition, and the World Health Organization Classification of Head and Neck Tumours, 5th Edition * Covers numerous new diagnostic entities, including intraductal carcinoma, sclerosing polycystic adenoma, microsecretory adenocarcinoma, adamantinoma-like Ewing sarcoma, SMARCB1- and SMARCA4-deficient carcinomas, and HPV-related multiphenotypic sinonasal carcinoma * Contains major updates on sinonasal tract, salivary gland, and odontogenic tumors; oropharyngeal squamous cell carcinoma and its correct classification and staging; the recent significant reclassification of neuroendocrine tumors; and changes in terminology and identification for head and neck soft tissue tumors * Suggests supporting studies in a realistic clinical context, with tables and immunohistochemical charts that assist with management decisions and prognostic outcome predictions * Features more than 3,200 images, including full-color drawings of head and neck anatomy, development pathway drawings, staging protocol illustrations, and genetic pathway graphics; radiologic images, clinical photographs, and gross images; and histology, histochemistry, immunohistochemistry, in situ hybridization, and molecular images; as well as more than 2,600 additional online-only images * Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care * Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

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Price: 252.99 EUR excl. shipping